Filesystem corruption

We have had 2 Windows 10 Pro systems that have had filesystem corruption since installing secure lockdown MAE.
Each computer was configured with a 2nd administrator account.
Windows updates are still enabled.
There is only one application that is enabled on each machine.
We have also installed other computers without Secure Lockdown at the same time and we have not encountered any filesystem corruption on those.
Any suggestions as to what could be causing the filesystem corruption?

Please provide more detail with regard to file corruption. What files are being corrupted and what is indicating that those files are corrupted.