Is it necessary to disable windows defender?

The documentation says "Secure Lockdown needs to write to the HKLM portion of the Windows Registry and some antivirus software prevents this."  

I interpret "some" to mean third-party software.  So, is it necessary to disable Windows Defender?  I have a client who I think will be quite reluctant to have Windows Defender disabled.

Thanks!

Windows Defender does not need to be disabled and does not interfere with Secure Lockdown.